Week 10 of the college football season brings two top matchups in the Big Ten, with third-ranked Penn State hosting No. 4 Ohio State and the top-ranked Oregon Ducks visiting the Big House to take on Michigan.

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Both away teams are favorites, but will the Ducks cover the 14.5-point lead in Ann Arbor and remain undefeated? And will the Buckeyes win at Beaver Stadium – another hostile environment – ​​and hand the Nittany Lions their first loss of the season?

Other exciting Big Ten matchups this week include: 24th-ranked Minnesota, Illinois; No. 13 Indiana at Michigan State; Wisconsin at Iowa; and USC in Washington.

Check out this week's college football odds and score predictions for select games from the CFB coverage team at The Oregonian/OregonLive.

No. 1 Oregon (8-0, 5-0) at Michigan (5-3, 3-2)

Game details: 12:30 p.m. PT Saturday at Michigan Stadium in Ann Arbor

TV channels and live stream: CBS and Paramount+

Latest line: Oregon until May 14th

Over/Under: 44.5

Predictions

Ryan Clarke: Oregon 31, Michigan 13

James Crepea: Oregon 35, Michigan 14

Nick Daschel: Oregon 31, Michigan 27

Aaron Fentress: Oregon 33, Michigan 13

Joe Freeman: Oregon 35, Michigan 17

Sean Meagher: Oregon 38, Michigan 20

Joel Odom: Oregon 38, Michigan 24

Bill Oram: Oregon 33, Michigan 21

No. 4 Ohio State (6-1, 3-1) and No. 3 Penn State (7-0, 4-0)

Game details: 9 a.m. PT Saturday at Beaver Stadium in University Park, Pennsylvania

TV channels and live stream: Fox and Fox Sports Live

Latest line: Ohio State by 3

Over/Under: 46.5

Predictions

Ryan Clarke: Ohio State 27, Penn State 20

James Crepea: Ohio State 28, Penn State 27

Nick Daschel: Ohio State 23, Penn State 20

Aaron Fentress: Ohio State 27, Penn State 23

Joe Freeman: Ohio State 27, Penn State 24

Sean Meagher: Penn State 28, Ohio State 27

Joel Odom: Ohio State 34, Penn State 31

Bill Oram: Penn State 20, Ohio State 17

Minnesota (5-3, 3-2) at No. 24 Illinois (6-2, 3-2)

Game details: 9 a.m. PT Saturday at Memorial Stadium in Champaign, Illinois

TV channels and live stream: FS1 and Fox Sports Live

Latest line: Minnesota at 3

Over/Under: 45.5

Predictions

Ryan Clarke: Illinois 28, Minnesota 17

James Crepea: Illinois 28, Minnesota 24

Nick Daschel: Illinois 27, Minnesota 21

Aaron Fentress: Illinois 24, Minnesota 22

Joe Freeman: Minnesota 23, Illinois 20

Sean Meagher: Illinois 34, Minnesota 24

Joel Odom: Minnesota 19, Illinois 16

Bill Oram: Illinois 28, Minnesota 16

Northwestern (3-5, 1-4) at Purdue (1-6, 0-4)

Game details: 9 a.m. PT Saturday at Ross-Ade Stadium in West Lafayette, Indiana

TV channels and live stream: Big Ten Network and Fox Sports Live

Latest line: Purdue by 1.5

Over/Under: 44.5

Predictions

Ryan Clarke: Northwestern 20, Purdue 18

James Crepea: Northwestern 31, Purdue 21

Nick Daschel: Northwest 30, Purdue 27

Aaron Fentress: Purdue 25, Northwestern 23

Joe Freeman: Northwestern 23, Purdue 20

Sean Meagher: Northwestern 27, Purdue 14

Joel Odom: Northwestern 30, Purdue 24

Bill Oram: Northwest 42, Purdue 40

No. 13 Indiana (8-0, 5-0) at Michigan State (4-4, 2-3)

Game details: 12:30 p.m. PT Saturday at Spartan Stadium in East Lansing, Michigan

TV channels and live stream: peacock

Latest line: Indiana at 8

Over/Under: 53.5

Predictions

Ryan Clarke: Indiana 37, Michigan State 10

James Crepea: Indiana 35, Michigan State 21

Nick Daschel: Indiana 41, Michigan State 21

Aaron Fentress: Indiana 33, Michigan State 19

Joe Freeman: Indiana 30, Michigan State 24

Sean Meagher: Indiana 42, Michigan State 14

Joel Odom: Indiana 30, Michigan State 20

Bill Oram: Indiana 31, Michigan State 10

UCLA (2-5, 1-4) at Nebraska (5-3, 2-3)

Game details: 12:30 p.m. PT Saturday at Memorial Stadium in Lincoln, Nebraska

TV channels and live stream: Big Ten Network and Fox Sports Live

Latest line: Nebraska at 7

Over/Under: 39.5

Predictions

Ryan Clarke: Nebraska 30, UCLA 20

James Crepea: Nebraska 31, UCLA 17

Nick Daschel: Nebraska 21, UCLA 20

Aaron Fentress: Nebraska 27, UCLA 17

Joe Freeman: Nebraska 25, UCLA 17

Sean Meagher: Nebraska 30, UCLA 17

Joel Odom: Nebraska 38, UCLA 21

Bill Oram: Nebraska 35, UCLA 13

Wisconsin (5-3, 3-2) at Iowa (5-3, 3-2)

Game details: 4:30 p.m. PT Saturday at Kinnick Stadium in Iowa City, Iowa

TV channels and live stream: NBC and Peacock

Latest line: Iowa by 2.5

Over/Under: 41.5

Predictions

Ryan Clarke: Wisconsin 28, Iowa 10

James Crepea: Iowa 24, Wisconsin 21

Nick Daschel: Wisconsin 26, Iowa 22

Aaron Fentress: Wisconsin 26, Iowa 24

Joe Freeman: Wisconsin 23, Iowa 21

Sean Meagher: Iowa 23, Wisconsin 20

Joel Odom: Iowa 20, Wisconsin 17

Bill Oram: Iowa 37, Wisconsin 28

USC (4-4, 2-4) at Washington (4-4, 2-3)

Game details: 4:30 p.m. PT Saturday at Husky Stadium in Seattle

TV channels and live stream: Big Ten Network and Fox Sports Live

Latest line: USC by 1.5

Over/Under: 55.5

Predictions

Ryan Clarke: Washington 20, USC 17

James Crepea: USC 35, Washington 28

Nick Daschel: USC 38, Washington 31

Aaron Fentress: Washington 31, USC 20

Joe Freeman: USC 30, Washington 27

Sean Meagher: USC 28, Washington 21

Joel Odom: USC 31, Washington 20

Bill Oram: Washington 24, USC 21