The 49ers had a tumultuous start to the season, which included a 24-23 loss to the Arizona Cardinals last week. The Seahawks had a strong start to the season, winning their first three games, but suffered a loss in their final two games.

Quarterback Brock Purdy completed 19 of 5 passes for 244 yards, one touchdown and two interceptions against the Cardinals. The 49ers have struggled to stay healthy this season. The biggest name is running back Christian McCaffrey, who hasn't played all season because of calf and Achilles tendonitis. Safety Talanoa Hufanga (wrist) and kicker Jake Moody (right ankle) are listed on the 49ers' injury report this week after not participating in practice on Wednesday.

Quarterback Geno Smith had to do a little bit of everything on offense in last week's 29-20 loss to the New York Giants. Smith completed 28 of 40 passes for 284 yards and a touchdown. He also led the Seahawks' rushing attack with 72 yards on four carries.