Lady Gaga has released “Disease,” the lead single from her upcoming seventh studio album, due out early next year. The song is the artist's first solo single since 2022's “Hold My Hand” and comes just a month after the release of harlequinthe accompanying album Joker: Folie à Deuxthat quietly came and went amidst the film's tepid performance at the box office.

Just in time for Halloween, Gaga revisits some of the tricks of her early heyday in “Disease” – namely the macabre imagery and bold EDM style of 2009 The Fame Monster and 2011 Born this way. Produced by Gaga, Cirkut and Andrew Watt, the track is driven by a hard industrial beat and a smacking bassline that have enough power to support Gaga's characteristically bombastic delivery.

The lyrics rely heavily on clichés and touch on similar themes to “Bad Romance” and “The Cure”: “Screamin' for me, baby/Like you're gonna die/Poison on the inside/I could be your antidote tonight.” However, like “Teeth” and “Born This Way,” the track's dungeon-deep production proves satisfying enough to even withstand a line like “I can smell your sickness.”

Listen to “Disease” below: