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Patrick Mahomes is having his worst season statistically and the Chiefs keep losing playmakers due to injuries.

The two-time defending Super Bowl champions are already 6-0.

Kansas City is the only undefeated team in the NFL after one season Ugly 28:18 win over San Francisco in a Super Bowl rematch on Sunday that looked more like a preseason game.

Mahomes, a two-time NFL MVP and three-time Super Bowl MVP, threw two picks and posted a career-worst passer rating of 44.4 against the 49ers, but made enough plays, including a nifty 33-yard run, to give the Chiefs the lead to bring their twelfth consecutive victory dating back to last year.

Mahomes has more interceptions (eight) than touchdowns (six) this season and a passer rating of 82.5, the lowest of his career. But a stingy defense and strong running game have paved the way for Kansas City, which lost receivers Jaylen Watson and JuJu Smith-Schuster to injuries in its recent win.

The Chiefs are already without No. 1 receiver Rashee Rice and top running back Isiah Pacheco, and Marquise “Hollywood” Brown still has to play.

Nevertheless, the Chiefs continue to win. It's a credit to coach Andy Reid and defensive coordinator Steve Spagnuolo.

“It’s about us getting better as the year goes on and how we can continue to improve from our last game to now,” Travis Kelce said. “There are a lot of doubts about what we can do offensively at the moment with the guys we have and I think we showed everyone today that we can score points.”

Unlike Kansas City, Brock Purdy and the 49ers (3-4) have not overcome a series of injuries to several key players. They have been inconsistent, error-prone and bear little resemblance to the team that reached the NFC title each of the last three seasons.

Purdy threw three interceptions against Kansas City and had the worst passer rating of his career at 36.7.

Now the 49ers have to cope with another serious setback. Receiver Brandon Aiyuk suffered a knee injury that coach Kyle Shanahan fears is a season-ending ligament tear. Deebo Samuel was limited to four snaps against Kansas City due to illness and Jauan Jennings was sidelined with a hip injury. All-Pro running back Christian McCaffrey did not play this season.

“Is there more pressure for me to put on a Superman cape and do more? No,” Purdy said. “I think who we have and the players we have stepping up in those positions, they've done a great job and we have a lot of talent in my eyes. That’s on me and we’re all just going to continue to grow and fight on this journey together.”

Injury week 7

Deshaun Watson appears to be done for the season. Jayden Daniels' sensational rookie year is on hold. Aidan O'Connell is also out.

There have been several serious injuries across the league.

Watson appeared to have torn his Achilles tendon in Cleveland's loss to Cincinnati. The Browns (1-6) made the playoffs last year after Watson sat out this season, but they have no chance this season.

Daniels, who is having an exceptional rookie season, injured his ribs in Washington's loss to Carolina. Daniels is scheduled to be tested on Monday, but the NFC East-leading Commanders (5-2) should bring him back at some point.

O'Connell had to miss his first start of the season due to a thumb injury and the Raiders lost to the Rams. He will be out indefinitely as Las Vegas (2-5) returns Gardner Minshew.

Statement made

The NFC North still runs through Detroit.

Jared Goff had another outstanding game, leading the Lions (5-1) to a 31-29 win at Minnesota, handing the Vikings their first loss of the season.

Goff, Amon-Ra St. Brown and Jahmyr Gibbs were sensational in the NFC North showdown and Detroit's defense stepped up in its first game without Aidan Hutchinson.

Russ cooked

Many analysts, including former players, questioned Mike Tomlin's decision to sign Russell Wilson after Justin Fields helped the Steelers get off to a 4-2 start.

Wilson silenced the doubters with an impressive performance in his Pittsburgh debut.

Wilson shook off early rust in his first start since Dec. 24, throwing for 264 yards and two touchdowns, running for a score and posting a passer rating of 109.0 to lead the Steelers (5-2) to a 37-15 Victory over the Steelers to lead New York Jets.

Wilson, who lacks Fields' speed and scrambling ability, threw several perfect deep balls and lobs to George Pickens and other receivers.

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AP NFL: https://apnews.com/hub/nfl