Titans storyline to watch: The Titans' passing game got off to a terrible start, including a 95-yard passing performance from QB Will Levis last week. Through five games, Tennessee's offense is averaging 135 yards per game, which is 31st in the league. Offensive coordinator Nick Holz said the unit watched every passing play to figure out what was going on. Look for the Titans to get into the passing game early against the Bills, with Levis primarily focused on getting the ball to receiver Calvin Ridley. – Turron Davenport

Bill's plot to watch: The Bills made a big move to improve their wide receiver group this week by adding Amari Cooper. It remains to be seen what role he can play with the team this week in such limited time, but the challenge, no matter how much Cooper plays against the Titans, will be putting together drives. Tennessee's defense leads the NFL with 248.8 yards allowed per game, while the Bills have averaged 290.3 yards per game and allowed no more than 23 points over the last three games. It will be crucial to change this trend. — Alaina Getzenberg

Statistics you should know: The Titans lead the NFL in total defense (248.8 yards per game), which is the third-fewest yards per game allowed in the first five games since 1976.

Bold prediction: Cooper will record a 40-yard reception in his Bills debut. The Browns successfully used Cooper as a deeper threat last year. Buffalo will be happy to have another depth option for QB Josh Allen. — Walder

Fantasy X Factor: Titans RB Tony Pollard. He has scored 15 or more fantasy points in four of five games. He has been one of the few consistent fantasy options for the Titans and faces a huge workload with Tyjae Spears dealing with a hamstring injury. Pollard faces a Bills defense that has allowed running backs the second-most fantasy points per game. — Moody

Betting nugget: The Bills are 1-6 ATS in their last seven games, scoring at least one touchdown.

Kahler's choice: Bills 27, Titans 21

Moody's selection: Bills 27, Titans 10

Walder's choice: Bills 27, Titans 13

FPI forecast: BUF, 71.4% (average 8.6 points)