The Los Angeles Chargers are one of nine away teams favored by oddsmakers in Week 6. Los Angeles faces the Denver Broncos and surprisingly faces an opponent that is on a three-game winning streak.

With head coach Sean Payton, the Broncos are a difficult matchup from week to week. Payton and Denver have already beaten the Raiders and are preparing for this week's division game against the Chargers. Denver is looking for another win in what could be the toughest division in the AFC.

The Broncos boast the second-best defense in the NFL, led by an elite secondary and a frenetic line with the seventh-highest pressure rate in the NFL at a whopping 25.1 percent. There's more bad news for Jim Harbaugh and Chargers quarterback Justin Herbert – Denver sacked opposing QBs on 10.8 percent of its dropbacks.

Neither the Broncos nor the Chargers have enough talent on offense to be a consistent threat through the air, and both offensive lines have holes that leave quarterbacks with little time to throw. But the Chargers have embraced Harbaugh's floor philosophy. Running back JK Dobbins averages 6.1 yards per carry. At this rate, he could beat his previous season best by several meters before the middle of the season.

Denver quarterback Bo Nix has proven he is a quick learner. He threw four picks in his first two NFL games. The rookie hasn't thrown an interception since then. He had two TD passes in a win over Las Vegas last week, and for the first time his completion percentage and QBR rose to the level his team needed to be competitive.

This mile-long duel could develop into a muscle-on-muscle game of O-line versus D-line. Or both teams use their pass rush to cause turnovers and light up the scoreboard. Whatever happens, the rivalry between the Chargers and Broncos divisions with top coaches and quarterbacks is something to keep an eye on.

All odds from BetMGM. Looking for NFL tickets? Find them here.

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Los Angeles Chargers and Denver Broncos odds

How to watch Chargers vs. Broncos

• Venue: Empower Field at Mile High – Denver
• Time: 4:05 p.m. ET
• TV: CBS
• Streaming: Fubo (try for free)

Expert tips for Chargers vs. Broncos

Read more about NFL Week 6

Odds, expert picks, previews: Drake Maye in, Saleh out and Lamar Jackson vs. Jayden Daniels headline a wild week

2024 NFL Playoff Predictions: The Athletic's model predicts the field

Best Bets Week 6: The Commanders platoon continues to cover

(Photo by Bo Nix: Luke Hales/Getty Images)